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Render Timestamp: 2024-11-14T22:21:35.462Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-10-02 19:16:11.198
Product last modified at: 2024-11-05T01:30:09.343Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

Z-VAD(OMe)-FMK #60332

    Product Information

    Product Usage Information

    Z-VAD(OMe)-FMK is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 1 mg of powder in 213.9 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used as a pre-treatment at 5-100 μM for 1 hr.

    Storage

    Store lyophilized or in solution at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 467.5 g/mol
    Purity >95%
    Molecular Formula C22H30FN3O7
    CAS 187389-52-2
    Solubility Soluble in DMSO at 5mg/ml.

    Background

    The synthetic peptide Z-VAD(OMe)-FMK is a cell permeable, irreversible pan-caspase inhibitor that displays non-cytotoxic effects (1-4). Z-VAD(OMe)-FMK prevents caspase-3 from adopting its active form and thereby blocks apoptosis (5). Research studies show that Z-VAD(OMe)-FMK also inhibits other enzymes, including cathepsin B, PNGase, and picornaviral 2A proteinases (6-8). Additional studies demonstrate that Z-VAD(OMe)-FMK can inhibit mitogen-induced T cell proliferation (2,9,10).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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