Render Target: SSR
Render Timestamp: 2024-10-24T19:16:38.301Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-04-24 09:10:43.328
Product last modified at: 2024-05-30T07:04:35.046Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

WHI-P131 #29832

    Product Information

    Product Usage Information

    WHI-P131 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 998 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at 4ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 333.8 g/mol
    Purity >98%
    Molecular Formula C16H15N3O3 • HCl
    CAS 202475-60-3
    Solubility Soluble in DMSO at 50 mg/ml.

    Background

    WHI-P131 is a potent and selective inhibitor of Janus kinase 3 (Jak3) (IC50 = 78 μM) and glioblastoma cell adhesion and migration (1,2). This novel quinazoline derivative inhibits the enzymatic activity of constitutively active Jak3 without affecting Jak1, Jak2, or other family tyrosine kinases (1). WHI-P131 has also been shown to inhibit thrombin-induced tyrosine phosphorylation of Stat1 and Stat3. These properties make this compound useful when studying different diseases such as acute lymphoblastic leukemia, glioblastoma multiforme, and thromboembolism (1-3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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