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Render Timestamp: 2024-12-19T20:42:40.794Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-19 21:57:43.390
Product last modified at: 2024-12-17T18:56:00.720Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Verapamil (Hydrochloride)

Verapamil (Hydrochloride) #49079

    Product Information

    Product Usage Information

    Verapamil (Hydrochloride) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.02 ml of water. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 491.1 g/mol
    Purity >98%
    Molecular Formula C27H38N2O4 • HCl
    CAS 152-11-4
    Solubility Soluble in water at 25 mg/ml.

    Background

    Verapamil (Hydrochloride) is a phenylalkylamine racemic mixture that inhibits the influx of extracellular calcium ions into myocardial and vascular smooth muscle cells by blocking L-type calcium channels and is commonly used in the treatment of high blood pressure, angina, and heart arrhythmias (1). Research has shown that Ca2+ channel blockers, such as Verapamil (Hydrochloride), can mediate Influenza A viral entry into cells (2). Studies have also shown Verapamil (Hydrochloride) to be an inhibitor of drug efflux pump proteins, such as P-glycoprotein, resulting in the reversal of multidrug resistance by tumor cells (3). As an L-type calcium channel antagonist, Verapamil (Hydrochloride) effectively inhibits Ebolaviruses (EBOV) infection with an IC50 value of 4 μM (4).

    限制使用

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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