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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Valinomycin

Valinomycin #49615

    Product Information

    Product Usage Information

    Valinomycin is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 10 mg of powder in 900 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 1111.3 g/mol
    Purity >98%
    Molecular Formula C54H90N6O18
    CAS 2001-95-8
    Solubility Soluble in DMSO at 25 mg/ml or ethanol at 25 mg/ml.

    Background

    Valinomycin, also known as NSC 122023, is a naturally occurring antibiotic consisting of a cyclized dodecadepsipeptide isolated from various strains of the genus Streptomyces. Valinomycin is a highly selective potassium ionophore that transports K+ across lipid membranes inducing cell death through depolarization of the mitochondrial membrane (1). Studies have investigated the critical role of potassium in viral infections (2). Valinomycin has demonstrated the ability to block viral fusion with endosomal membranes, affecting viral transcription and inhibiting viral replication, by collapsing the membrane potential (3,4). Research studies of severe acute respiratory syndrome (SARS) viral replication in Vero E6 cells identified Valinomycin as the most potent inhibitor (EC50 = 0.85 μM) as compared with other possible treatments, such as Reserpine (EC50 = 3.4 μM) and Aescim (EC50 = 6.0 μM) (5).

    限制使用

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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