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Render Timestamp: 2024-12-19T20:42:40.710Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-20 06:16:54.138
Product last modified at: 2024-12-17T18:55:21.472Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. UNC1999

UNC1999 #46080

    Product Information

    Product Usage Information

    UNC1999 is supplied as a lyophilized powder. For a 5 mM stock, reconstitute the 1 mg in 350.97 μl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 5 nM -5 μM for 2-48 hr.

    Storage

    Store lyophilized or in solution at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 569.8 g/mol
    Purity >98%
    Molecular Formula C33H43N7O2
    CAS 1431612-23-5
    Solubility Soluble in DMF at 1mg/ml and EtOH at 100ug/ml.

    Background

    UNC1999 inhibits EZH2 and EZH1 histone-lysine N-methyltransferase activity through competitive inhibition of the cofactor S-Adenosyl-l-methionine (SAM). The UNC1999 inhibitor displays potent specificity relative to other histone methyltransferases. IC50 values for EZH2 and EZH1 are 2 nM and 45 nM, respectively (1). Research studies demonstrate that UNC1999 effectively blocks histone H3 lysine 27 (H3K27) methylation. UNC1999 induces anti-proliferation, cell differentiation, and apoptosis, while exhibiting low cellular toxicity (1,2).

    限制使用

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