Render Target: SSR
Render Timestamp: 2024-12-26T18:46:41.516Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-19 21:57:44.234
Product last modified at: 2024-12-17T19:05:20.275Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Triptolide

Triptolide #97539

    Product Information

    Product Usage Information

    Triptolide is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.38 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 360.4 g/mol
    Purity >98%
    Molecular Formula C20H24O6
    CAS 38748-32-2
    Solubility Soluble in DMSO at 7 mg/ml.

    Background

    Triptolide is an immunosuppressive and anti-inflammatory compound produced by the thunder god vine, Tripterygium wilfordii Hook F (1). Covalent binding of Triptolide to human XPB/ERCC3 inhibits its DNA-dependent ATPase activity and prevents nucleotide excision repair by the TFIIH complex (2). Triptolide has proven to be an effective synergistic therapy for inhibition of pancreatic cancer cell growth, with IC50 values of 0.01 µM and 0.02 µM in Capan-1 and Capan-2 adenocarcinoma cells, respectively (3,4). In addition to its anti-tumor activity, Triptolide has shown antiviral efficacy in HIV-1 and dengue virus via inhibition of Tat protein and COX-2, respectively (5,6).

    限制使用

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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