T-705 (Favipiravir) #57214

T-705 (Favipiravir) is a potent antiviral agent that has shown effectiveness against influenzas A, B, and C with IC₅₀ values as follows: A (H1N1) = 0.03-0.20 µg/ml, A (H2N2) = 0.01-0.30 µg/ml, A (H3N2) = 0.08-0.48 µg/ml, A (H4N2) = 0.14-0.15 µg/ml, A (H7N2) = 0.24-1.60 µg/ml, B = 0.04-0.09 µg/ml, and C = 0.03-0.06 µg/ml (1,2). T-705 (Favipiravir) becomes activated by phosphoribosylation to form T-705 (Favipiravir)-RTP that is recognized by RNA polymerase, inhibiting RNA-dependent RNA polymerase (RdRP). This activity makes T-705 (Favipiravir) an effective inhibitor of other RNA viruses, such as arena-, phlebo-, hanta-, flavi-, entero-, and alphavirus. The antiviral capability of T-705 (Favipiravir) makes it a compound of interest when studying SARS-CoV-2 infection (3).