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Stattic #97598

Stattic: Image 1
Western blot analysis of extracts from Jurkat cells, untreated (-) or treated with Human Interferon-α1 (hIFN-α1) #8927 (100 ng/ml, 5 min; +) with or without pretreating the cells with Stattic (10 μM, 2 hr; +), using Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb #9145 (upper), Stat3 (D1B2J) Rabbit mAb #30835 (middle), and β-Actin (D6A8) Rabbit mAb #8457 (lower).
1/2

To Purchase # 97598**

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Product Information

Product Usage Information

Stattic is supplied as a lyophilized powder. For a 40 mM stock, reconstitute 10 mg of powder in 1.18 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 211.2 g/mol
Purity >98%
Molecular Formula C8H5NO4S
CAS 19983-44-9
Solubility Soluble in DMSO at 10 mg/ml or ethanol at 1 mg/ml.

Background

Stattic is a nonpeptidic selective Stat3 inhibitor. This small molecule prevents the binding of tyrosine-phosphorylated peptide motifs to the Stat3 SH2 domain, inhibiting Stat3 activation, dimerization, and nuclear translocation with an IC50 value of 5.1 μM (incubated for 1 hour at 37°C) (1). Stattic blocks IL-6-induced Stat3 activation, reducing cell viability in tumor cells (2). Treatment with 10 μM induces apoptosis in Stat3-dependent cancer cell lines MDA-MB-231 and MDA-MB-435S (1).

限制使用

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