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XML generation date: 2024-09-19 21:57:41.918
Product last modified at: 2024-11-11T15:15:10.728Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Stattic

Stattic #97598

    Product Information

    Product Usage Information

    Stattic is supplied as a lyophilized powder. For a 40 mM stock, reconstitute 10 mg of powder in 1.18 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 211.2 g/mol
    Purity >98%
    Molecular Formula C8H5NO4S
    CAS 19983-44-9
    Solubility Soluble in DMSO at 10 mg/ml or ethanol at 1 mg/ml.

    Background

    Stattic is a nonpeptidic selective Stat3 inhibitor. This small molecule prevents the binding of tyrosine-phosphorylated peptide motifs to the Stat3 SH2 domain, inhibiting Stat3 activation, dimerization, and nuclear translocation with an IC50 value of 5.1 μM (incubated for 1 hour at 37°C) (1). Stattic blocks IL-6-induced Stat3 activation, reducing cell viability in tumor cells (2). Treatment with 10 μM induces apoptosis in Stat3-dependent cancer cell lines MDA-MB-231 and MDA-MB-435S (1).

    限制使用

    除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。 任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受， 否书均被拒书，并且无效。

    专品专有“专供研究使用”的专专或专似的专专声明， 且未专得美国食品和专品管理局或其他外国或国内专管机专专专任何用途的批准、准专或专可。客专不得将任何专品用于任何专断或治专目的， 或以任何不符合专专声明的方式使用专品。CST 专售或专可的专品提供专作专最专用专的客专，且专用于研专用途。将专品用于专断、专防或治专目的， 或专专售（专独或作专专成）或其他商专目的而专专专品，均需要 CST 的专独专可。客专：(a) 不得专独或与其他材料专合向任何第三方出售、专可、 出借、捐专或以其他方式专专或提供任何专品，或使用专品制造任何商专专品，(b) 不得复制、修改、逆向工程、反专专、 反专专专品或以其他方式专专专专专品的基专专专或技专，或使用专品开专任何与 CST 的专品或服专专争的专品或服专， (c) 不得更改或专除专品上的任何商专、商品名称、徽专、专利或版专声明或专专，(d) 只能根据 CST 的专品专售条款和任何适用文档使用专品， (e) 专遵守客专与专品一起使用的任何第三方专品或服专的任何专可、服专条款或专似专专

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