SC-79 #90851
Product Information
Product Usage Information
SC-79 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 0.91 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Product Description
| Molecular Weight | 364.8 g/mol |
| Purity | >98% |
| Molecular Formula | C17H17ClN2O5 |
| CAS | 305834-79-1 |
| Solubility | Soluble in DMSO at 100 mg/mL or ethanol at 40 mg/mL. |
Background
The small-molecule SC-79 activates cytosolic Akt (PKB, protein kinase B) and inhibits Akt translocation to the membrane. Binding of SC-79 to Akt promotes interaction between Akt and the protein kinase PDK1, leading to phosphorylation of Akt at Thr308 and Ser473 (1). In a mouse model of acute liver failure, SC-79 treatment protects hepatocytes from apoptosis by inhibiting Akt-mediated aggregation of Fas and by blocking recruitment of FADD and procaspase-8 into the death-inducing signaling complex (2). Likewise, SC-79 protects hepatocytes from tumor necrosis factor-α (TNF-α)-induced apoptosis and mice from induced liver injury and damage (3). In a rat model of alcohol-induced osteonecrosis, SC-79 exposure leads to activation of cytosolic Akt and attenuation of bone tissue morphological changes (4). SC-79 treatment of neuroblastoma cells and murine dopaminergic neurons leads to Akt activation and protection from hydrogen peroxide-induced apoptosis and necrosis (5).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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