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Santacruzamate A (CAY10683)

Santacruzamate A (CAY10683) #69552

Name: Santacruzamate A (CAY10683)
Price: 62.00 USD
Availability: InStock

Product Information

Product Usage Information

Santacruzamate A (CAY10683) is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.19 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	278.4 g/mol
Purity	>98%
Molecular Formula	C₁₅H₂₂N₂O₃
CAS	1477949-42-0
Solubility	Soluble in DMSO at 25 mg/ml or ethanol at 20 mg/ml.

Background

Santacruzamate A (CAY10683) is a cytotoxin isolated from the Panamanian marine cyanobacterium cf. Symploca sp., and is a highly selective inhibitor of histone deacetylases (HDACs), specifically HDAC2 (IC₅₀ = 0.119 nM) and HDAC6 (IC₅₀ = 434 nM) (1). This small molecule has been shown to induce apoptosis via transcriptional inhibition of HDAC2, resulting in an increase of p21 Waf1/Cip1 and p19INK4d expression when combined with an HDAC1 inhibitor (2). Santacruzamate A (CAY10683) has also demonstrated the ability to attenuate amyloid-β protein (Aβ) fragment (Aβ_25-35)-induced toxicity through enhancing endoplasmic reticulum (ER) stress tolerance in mice (3). Additionally, HDAC2 has been recognized as a host immune response to the influenza A virus (IVA) and several other viruses, making HDAC inhibitors important compounds to study in relation to viral diseases (4,5).

限制使用

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For Research Use Only. Not For Use In Diagnostic Procedures.

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