RIPA-56 #67765

RIPA-56 is a potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) kinase with an IC₅₀ value of 13 nM, with no effect on RIP3 kinase activity at a 10 μM concentration. RIPA-56 has been shown to reduce TNFα-induced mortality and multiorgan damage in systemic inflammatory response syndrome (SIRS) (1). Blocking the activity of RIP1 kinase allows for cell survival and proliferation in the presence of death receptor ligands. In vivo studies have also shown that necroptosis can be inhibited in the testes of busulfan-induced mice by the suppression of RIP1 kinase with RIPA-56 (2). This small molecule can protect myelin structures by blocking the demyelination and inflammation of spinal cord white matter in mice experimental autoimmune encephalomyelitis (EAE)-induced models, halting the progression of multiple sclerosis (MS) (3).