Render Target: SSR
Render Timestamp: 2024-12-19T20:42:22.924Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-04-24 09:10:43.483
Product last modified at: 2024-12-17T19:00:37.228Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. PP2

PP2 #73901

    Product Information

    Product Usage Information

    PP2 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.1 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 301.8 g/mol
    Purity >98%
    Molecular Formula C15H16CIN5
    CAS 172889-27-9
    Solubility Soluble in DMSO at 25 mg/ml or ethanol at 3 mg/ml with slight warming.

    Background

    PP2 is a potent and selective inhibitor of Src-family kinases. This small molecule inhibits Lck (IC50 = 4 nM), Fyn (IC50 = 5 nM), and Hck (IC50 = 5 nM) with little to no effect on ZAP-70 (IC50 > 100 µM) and JAK2 (IC50 > 50 µM) (1). Members of the Src family are involved in the regulation of cellular excitability and synaptic plasticity. Inhibition of Src family nonreceptor protein tyrosine kinases (PTKs) can decrease epileptiform activity, making PP2 an important compound when studying epilepsy and antiepileptic therapies (2).

    限制使用

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