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Render Timestamp: 2024-11-14T22:21:12.341Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-10-22 15:16:09.332
Product last modified at: 2024-10-23T07:00:56.795Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

PD 0325901 #79241

    Product Information

    Product Usage Information

    PD 0325901 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.03 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 482.2 g/mol
    Purity >98%
    Molecular Formula C16H14F3IN2O4
    CAS 391210-10-9
    Solubility Soluble in DMSO at 12 mg/ml.

    Background

    PD 0325901 is a potent and selective non-ATP competitive MEK inhibitor. This small molecule is highly effective at inhibiting cell growth and proliferation in various cancer cells (1). The potency of PD 0325901 has been illustrated by the inhibition of ERK phosphorylation in mouse and human cell models with an IC50 of 0.33 nM and between 20-50 nM, respectively (1,2). PD 0325901 increases the self-renewal of mouse embryonic stem cells (mESCs) by enhancing the expression of pluripotency genes and acts as an antagonist for retinoic acid (RA) induced cell differentiation (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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