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Render Timestamp: 2024-10-24T19:16:12.634Z
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XML generation date: 2024-09-20 06:22:13.001
Product last modified at: 2024-09-17T19:45:07.430Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Palbociclib

Palbociclib #47284

    Product Information

    Product Usage Information

    Palbociclib is supplied as a lyophilized powder. For a 2 mM stock, reconstitute 1 mg of powder in 1.1 ml of DMSO. Heating to 37ºC and/or additional vortexing may be required. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 447.5 g/mol
    Purity >98%
    Molecular Formula C24H29N7O2
    CAS 571190-30-2
    Solubility Soluble in DMSO at 2 mg/ml.

    Background

    Palbociclib, also known as PD 0332991, is a potent and selective inhibitor of cyclin-dependent kinase 4 (Cdk4, IC50 = 11nM) and cyclin-dependent kinase 6 (Cdk6, IC50 = 16nM). Phosphorylation of retinoblastoma protein (Rb) by Cdk4 and Cdk6 leads to G1-S phase advancement, which is an important checkpoint for cell division (1). This regulation of the cell cycle makes the activation and inhibition of Cdk4 and Cdk6 highly researched. Palbociclib has been shown to arrest the proliferation of 5T33MM tumor cells in vivo and ex vivo, and treatment with the compound has increased the survival rate of 5T33MM diseased mice (2).

    限制使用

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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