Paclitaxel #9807

Name: Paclitaxel
Price: 40.00 USD
Availability: InStock

Product Information

Product Usage Information

Paclitaxel is supplied as 1 mg powder. Store at or below -20ºC. Before use, dissolve powder in 1.15 ml DMSO to make a 1 mM paclitaxel stock solution. For working concentrations of 100 nM-1000 nM, dilute DMSO stock 1:10,000 to 1:1000. Treat cells with the desired concentration for 6-48 hours.

Storage

Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	853.9 g/mol
Purity	>99.5%
Molecular Formula	C₄₇H₅₁NO₁₄
CAS	33069-62-6
Solubility	Soluble in DMSO at 25mg/ml or EtOH at 20mg/ml.

Background

Paclitaxel belongs to the taxane family of antitumor and antileukemic agents (3). By binding to β-tubulin and promoting the assembly of microtubules, paclitaxel prevents microtubual depolymerization and blocks normal cell division (1-3). The microtubule dysfunction induced by paclitaxel results in aberrant cell mitosis and sometimes apoptosis. The IC₅₀ of paclitaxel-induced mitotic block is 4 nM (4).

限制使用

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For Research Use Only. Not For Use In Diagnostic Procedures.

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