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XML generation date: 2024-09-24 16:16:14.104
Product last modified at: 2024-11-06T17:45:10.093Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Oligomycin

Oligomycin #9996

    Product Information

    Product Usage Information

    Oligomycin is supplied as a lyophilized powder. For a 5 mM stock, reconstitute the 5 mg in 1.26 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 0.5 - 10 μM for 0.5 - 8 hours.

    Storage

    Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 791.1 g/mol
    Purity 97%
    Molecular Formula Isomer A: C45H74O11 Isomer B: C45H72O12 Isomer C: C45H74O10
    CAS 1404-19-9
    Solubility Soluble in DMSO at 300mg/ml and EtOH at 200mg/ml.

    Background

    During oxidative phosphorylation in mitochondria, the electron transport system pumps H+ from the matrix into the intermembrane compartment. This process generates a H+ gradient across the mitochondrial inner membrane. This H+ gradient is used to drive mitochondrial FoF1 ATPase to convert ADP to ATP. Oligomycin, an antibiotic from Streptomyces diastatochromogenes, blocks oxidative phosphorylation by binding to the Fo part of the ATPase to inhibit its activity (1-3).

    限制使用

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