NKY-80 #52184
Product Information
Product Usage Information
NKY-80 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 1 mg of powder in 0.44 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Product Description
| Molecular Weight | 229.2 g/mol |
| Purity | >98% |
| Molecular Formula | C12H11N3O2 |
| CAS | 299442-43-6 |
| Solubility | Soluble in DMSO at 40 mg/mL or ethanol at 5 mg/mL. |
Background
NKY-80 is an inhibitor of adenylyl cyclase (AC) catalytic activity, an essential enzyme that generates cyclic adenosine 3'5'-monophosphate (cAMP) from ATP. At least six distinct classes of ACs have been identified, with isozymes differing in cell localization, tissue distribution, and signaling pathways. NKY-80 is capable of blocking several different AC isozymes, inhibiting type V more strongly (IC50 = 8.3 μM) than type II (IC50 = 1.7 mM) or type III (IC50 = 132 μM). NKY-80 also potently inhibits AC type VI, with an affinity close to that of AC type V (1,2). In a rat model of Parkinson's disease, NKY-80 blocked increases of both [(3)H]-GABA release and cAMP production, indicating that AC V/VI expression is a major determinant of increased GABAergic transmission in rats with L-DOPA induced severe dyskinesia (3). In a study of immune response in insects, NKY-80 reduced levels of hemocyte mobilization in response to bacterial challenge, indicating a role for AC and cAMP in hemocyte regulation and the immune response (4).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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