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Render Timestamp: 2024-11-14T22:21:14.219Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-11-13 13:10:07.664
Product last modified at: 2024-11-11T22:15:09.099Z
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PDP - Template Name: Chemical Modulators
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Nigericin (sodium salt) #66419

    Product Information

    Product Usage Information

    Nigericin (sodium salt) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 669 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at 4ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 747 g/mol
    Purity >98%
    Molecular Formula C40H67O11 • Na
    CAS 28643-80-3
    Solubility Soluble in DMSO at 50 mg/ml and EtOH at 20 mg/ml.

    Background

    Nigericin (sodium salt) is an electroneutral K+/H+ ionophore derived from S. hygroscopicus. This antibiotic is lipophilic and selectively causes efflux of potassium across mitochondrial membranes (1,2). The ion exchange can lead to disruption of membrane potential, changes in pH, and cell death making the compound useful for studying areas of interests such as apoptosis, mitosis, and the immune response (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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