Render Target: SSR
Render Timestamp: 2024-12-19T20:42:09.842Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-19 21:57:43.675
Product last modified at: 2024-12-17T18:59:36.394Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Niclosamide

Niclosamide #69857

    Product Information

    Product Usage Information

    Niclosamide is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.02 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 327.1 g/mol
    Purity >98%
    Molecular Formula C13H8Cl2N2O4
    CAS 50-65-7
    Solubility Soluble in DMSO at 14 mg/ml or ethanol at 6 mg/ml.

    Background

    Niclosamide is a STAT3 inhibitor (IC50 = 0.25 μM) known to induce apoptosis and cell cycle arrest (1). This small molecule stimulates autophagy by reversibly inhibiting mammalian target of rapamycin complex 1 (mTORC1) signaling and inhibiting phosphorylation of ribosomal S6 kinases at certain concentrations (2). In clinical settings, Niclosamide has been used to treat parasitic-driven diseases in humans as an antihelminthic drug. Studies have shown Niclosamide to be an effective antiviral agent, inhibiting the replication of SARS-CoV (3).

    限制使用

    除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。 任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受， 否书均被拒书，并且无效。

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