Nelfinavir Mesylate #27793

Nelfinavir Mesylate, also known as AG-1343, is a potent antiviral inhibitor of HIV-1 protease with a K_i value of 2 nM, in vitro (1). This small molecule is an effective antitumor agent, known to induce endoplasmic reticulum (ER) stress, autophagy, and apoptosis in vitro and in vivo (2). Nelfinavir Mesylate has anti-microbial effects on malaria, tuberculosis, and SARS (3). It has also been used in therapies as an antifibrotic agent against pulmonary fibrosis in patients with systemic sclerosis (4). Nelfinavir Mesylate is known to reduce inflammation by activating protein phosphatase 2 (PP2) and blocking MAPK signaling in macrophages (5). Through a novel mechanism of heat shock protein 90 (HSP90) inhibition, Nelfinavir Mesylate selectively inhibits the growth of HER2-positive breast cancer cells in vitro (6).