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Render Timestamp: 2024-12-26T18:46:15.991Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-20 06:22:15.372
Product last modified at: 2024-12-17T18:49:49.530Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Necrostatin-1s

Necrostatin-1s #17802

    Product Information

    Product Usage Information

    Necrostatin-1s is supplied as a lyophilized powder. For a 20 mM stock, reconstitute 5 mg of powder in 900 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 277.7 g/mol
    Purity >98%
    Molecular Formula C13H12CIN3O2
    CAS 852391-15-2
    Solubility Soluble in DMSO at 25 mg/ml.

    Background

    Necrostatin-1s, also known as Nec-1s or 7-Cl-O-Nec-1, is a potent and selective inhibitor of necroptosis. This analog of Necrostatin-1 (Nec-1) has been shown to be a specific receptor-interacting protein kinase (RIPK) 1 inhibitor that is metabolically more stable than the other variants (1). Research studies have found that Nec-1s is more selective than Nec-1 and Nec-1i (inactive variant) due to the fact that both molecules have an inhibitory affect on indoleamine 2,3-dioxygenase (IDO), a potent immunosuppressive molecule (2). Evidence also suggests that Nec-1s is around two-times more effective at RIPK1 inhibition than Nec-1 (IC50 = 210 nM vs. 494 nM) (1).

    限制使用

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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