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Render Timestamp: 2024-11-14T22:21:07.449Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-09-19 21:57:43.272
Product last modified at: 2024-09-19T22:12:47.290Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Nafamostat Mesylate

Nafamostat Mesylate #38695

    Product Information

    Product Usage Information

    Nafamostat Mesylate is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 10 mg of powder in 1.23 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at 4ºC and use within 1 month or at -80ºC and use within 6 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 539.6 g/mol
    Purity >98%
    Molecular Formula C19H17N5O2 • 2CH3SO3H
    CAS 82956-11-4
    Solubility Soluble in DMSO at 50 mg/ml or water at 50 mg/ml.

    Background

    Nafamostat Mesylate, also known as FUT-175, is a potent and reversible, broad-spectrum serine protease inhibitor of trypsin (Ki = 15 nM), tryptase (Ki = 95.3 pM), and other additional proteases (1). This small compound has been identified as a key player in the disruption of the inflammatory response via inhibition of the complement system and coagulation cascade (2). Its wide range of inhibitory activity displays anti-cancer and anti-viral properties and has shown effective inhibition of MERS-CoV by preventing membrane fusion, making it a promising therapeutic candidate against the 2019-nCoV infection (EC50 = 22.50 μM) (3,4).

    限制使用

    除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。 任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受， 否书均被拒书，并且无效。

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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