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Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-09-19 21:57:42.822
Product last modified at: 2024-11-06T13:30:30.169Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Mitomycin C

Mitomycin C #51854

    Product Information

    Product Usage Information

    Mitomycin C is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 997 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 334.3 g/mol
    Purity >98%
    Molecular Formula C15H18N4O5
    CAS 50-07-7
    Solubility Soluble in DMSO at 15 mg/ml or water at 1 mg/ml with slight warming.

    Background

    Mitomycin C, also known as MMC, is an antitumor antibiotic isolated from Streptomyces caespitosus (1). When activated, this alkylating agent crosslinks double stranded DNA resulting in DNA damage (2). Mitomycin C has been found to have lethal effects on HeLa cells during the G1 phase of the cell cycle (3). DNA damage caused by Mitomycin C can lead to increased levels of p53 that can result in cell cycle arrest or apoptosis (4).

    限制使用

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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