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XML generation date: 2024-04-24 09:10:45.981
Product last modified at: 2024-05-30T07:07:57.034Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. MDL-28170 (Calpain Inhibitor III)

MDL-28170 (Calpain Inhibitor III) #10727

    Product Information

    Product Usage Information

    MDL-28170 (Calpain Inhibitor III) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.30 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 382.5 g/mol
    Purity >98%
    Molecular Formula C22H26N2O4
    CAS 88191-84-8
    Solubility Soluble in DMSO at 75 mg/ml.

    Background

    MDL-28170 (Calpain Inhibitor III) is a potent and selective inhibitor of Calpain-1 (mu-type) and Calpain-2 (M-type) (1). This cell-permeable small molecule has been shown to cross the blood-brain barrier and has demonstrated neuroprotective effects in several rodent models making it a useful tool for studying neurodegenerative disease and neurotrauma as well as ischemic reperfusion (2,3). MDL-28170 (Calpain Inhibitor III) has an EC50 value of 14 μM when tested in a cell-based assay and has shown to be an effective antiviral agent, inhibiting SARS-CoV replication in Vero 76 cells with an IC50 value of 10 μM (4,5).

    限制使用

    除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。 任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受， 否书均被拒书，并且无效。

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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