Render Target: SSR
Render Timestamp: 2024-12-19T20:42:04.450Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-19 21:57:43.502
Product last modified at: 2024-12-17T18:58:07.080Z
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PDP - Template Name: Chemical Modulators
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Losartan (potassium salt) #59489

    Product Information

    Product Usage Information

    Losartan (potassium salt) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.08 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at 4ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 461 g/mol
    Purity >99%
    Molecular Formula C22H22ClN6O • K
    CAS 124750-99-8
    Solubility Soluble in DMSO at 45 mg/ml or water at 45 mg/ml.

    Background

    Losartan (potassium salt) is a known angiotensin II receptor antagonist by selectively and competitively blocking the binding of the angiotensin II hormone (1). In clinical settings, it is useful as an antihypertensive agent and also displays neuroprotective effects against chronic fatigue stress (2,3). Losartan (potassium salt) inhibits collagen I synthesis and induces sirtuin 1 (SirT1) expression and activity (4,5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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