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Render Timestamp: 2024-12-19T20:42:03.750Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-07-08 15:11:12.739
Product last modified at: 2024-12-17T19:02:18.767Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. KU-55933

KU-55933 #83346

    Product Information

    Product Usage Information

    KU-55933 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.26 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 395.5 g/mol
    Purity >98%
    Molecular Formula C21H17NO3S2
    CAS 587871-26-9
    Solubility Soluble in DMSO at 40 mg/ml or ethanol at 20 mg/ml.

    Background

    KU-55933 is a potent and selective ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM and Ki = 2.2 nM). This small molecule has been shown to sensitize cancer cells to ionizing radiation and chemotherapeutic agents (1). Treating senescent cancer cells (MCF7, A549, and HCT 116) with KU-55933 results in decreased viability and cell death (2). KU-55933 has neuroprotective capabilities by preventing damage caused by oxidative stress (3).

    限制使用

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