INK128 #30690

Name: INK128
Price: 99.00 USD
Availability: InStock

Product Information

Product Usage Information

INK128 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.07 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	309.3 g/mol
Purity	>98%
Molecular Formula	C₁₅H₁₅N₇O
CAS	1224844-38-5
Solubility	Soluble in DMSO at 25 mg/ml.

Background

INK128, also known as MLN0128, is a second-generation active-site mTOR inhibitor (asTORi). Treating cells with INK128 leads to the dephosphorylation of mTOR downstream targets including p70 S6 kinase and 4E-BP1 (1,2). Research has proven that INK128 is an effective mTOR inhibitor because it targets both the mTORC1 and mTORC2 complexes at a high potency (K_i = 1.4nM) (1). Studies have shown that INK128 has anti-leukemic effects and can induce apoptosis at higher concentrations (3).

限制使用

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For Research Use Only. Not For Use In Diagnostic Procedures.

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