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Render Timestamp: 2024-12-19T20:42:02.924Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-20 06:22:12.875
Product last modified at: 2024-12-17T18:52:02.846Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. INK128

INK128 #30690

    Product Information

    Product Usage Information

    INK128 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.07 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 309.3 g/mol
    Purity >98%
    Molecular Formula C15H15N7O
    CAS 1224844-38-5
    Solubility Soluble in DMSO at 25 mg/ml.

    Background

    INK128, also known as MLN0128, is a second-generation active-site mTOR inhibitor (asTORi). Treating cells with INK128 leads to the dephosphorylation of mTOR downstream targets including p70 S6 kinase and 4E-BP1 (1,2). Research has proven that INK128 is an effective mTOR inhibitor because it targets both the mTORC1 and mTORC2 complexes at a high potency (Ki = 1.4nM) (1). Studies have shown that INK128 has anti-leukemic effects and can induce apoptosis at higher concentrations (3).

    限制使用

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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