Product Information

Product Usage Information

GSK343 is supplied as a lyophilized powder. For a 5 mM stock, reconstitute the 1 mg in 369.21 μl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 5 nM-5 μM for 2-48 hr.

Storage

Store lyophilized or in solution at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	541.7 g/mol
Purity	>98%
Molecular Formula	C₃₁H₃₉N₇O₂
CAS	1346704-33-3
Solubility	Soluble in DMSO at 15mg/ml and EtOH at 2mg/ml.

Background

GSK343 inhibits EZH2 and EZH1 histone-lysine N-methyltransferase activity through competitive inhibition of the cofactor S-Adenosyl-l-methionine (SAM). IC₅₀ values for EZH2 and EZH1 are 4 nM and 60 nM, respectively (1). Research studies show that GSK343 displays more than 1000-fold selectivity relative to other methyltransferases (1,2). These studies demonstrate that GSK343 induces cancer cell autophagy and enhances the anti-cancer effects of the multi-kinase inhibitor, sorafenib (3).

限制使用

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For Research Use Only. Not For Use In Diagnostic Procedures.

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GSK343 #66244