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Render Timestamp: 2024-12-19T20:41:59.606Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-04-24 09:10:44.942
Product last modified at: 2024-12-17T19:05:10.647Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Entacapone

Entacapone #96692

    Product Information

    Product Usage Information

    Entacapone is supplied as a lyophilized powder. For a 30 mM stock, reconstitute 10 mg of powder in 1.09 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 305.3 g/mol
    Purity >98%
    Molecular Formula C14H15N3O5
    CAS 130929-57-6
    Solubility Soluble in DMSO at 30 mg/ml or ethanol at 3 mg/ml.

    Background

    Entacapone, also known as OR-611, is a catechol O-methyltransferase (COMT) inhibitor with IC50 values ranging from 10 nM to 160 nM for rat duodenum and rat liver COMT, respectively (1,2). Taken as an adjuvant with levodopa/carbidopa therapy, entacapone blocks COMT methylation and subsequent degradation of plasma levodopa, prolonging and improving therapeutic response in Parkinson’s patients (3,4). Entacapone inhibition of COMT also works synergistically with (-)-Epigallocatechin-3-gallate (EGCG) to inhibit human and murine lung cancer cell growth in vitro (5).

    限制使用

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