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Render Timestamp: 2024-11-14T22:20:54.301Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-09-19 21:57:39.485
Product last modified at: 2024-10-31T21:00:09.752Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Dorsomorphin (Compound C)

Dorsomorphin (Compound C) #60887

    Product Information

    Product Usage Information

    Dorsomorphin (Compound C) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.25 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 399.5 g/mol
    Purity >98%
    Molecular Formula C24H25N5O
    CAS 866405-64-3
    Solubility Soluble in DMSO at 4 mg/ml with warming.

    Background

    Dorsomorphin (Compound C) is a potent and reversible AMP-activated protein kinase (AMPK) inhibitor that competes with ATP in the absence of AMP with a Ki value of 109 nM (1). This small compound is selective, displaying no significant inhibition of other kinases inclusive of ZAPK, SYK, PKCθ, PKA, and JAK3 (1). Research has shown that Dorsomorphin (Compound C) inhibits tumor cell proliferation and induces apoptosis through mechanisms independent of the AMPK pathway (2). This compound inhibits the effects that AICAR and metformin have on inactivating acetyl-CoA carboxylase (ACC) and selectively inhibits the BMP type I receptors ALK2, ALK3, and ALK6 (1,3). 

    限制使用

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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