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Dabrafenib (GSK2118436)

Dabrafenib (GSK2118436) #91942

Name: Dabrafenib (GSK2118436)
Price: 113.00 USD
Availability: InStock

Product Information

Product Usage Information

Dabrafenib (GSK2118436) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 962 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	519.6 g/mol
Purity	>98%
Molecular Formula	C₂₃H₂₀F₃N₅O₂S₂
CAS	1195765-45-7
Solubility	Soluble in DMSO at 30 mg/ml or ethanol at 1 mg/ml with slight warming.

Background

Dabrafenib (GSK2118436) is a selective and potent B-Raf inhibitor. The compound inhibits mutant B-Raf^V600E and B-Raf^V600K with IC₅₀ values of 0.6 nM and 0.5 nM, respectively, and is less effective at inhibiting wild-type B-Raf and C-Raf (IC₅₀ = 3.2 nM and 5.0 nM, respectively) (1). Dabrafenib (GSK2118436) has also been shown to inhibit cell proliferation and ERK signaling in melanoma cell lines carrying the B-Raf^V600R and B-Raf^V600D mutations as compared to wild-type B-Raf (2). The specificity of this compound makes it a useful reagent when studying metastatic melanoma with B-Raf mutations (3).

This product has applications to SARS-CoV-2 research into the mechanisms of the Novel Coronavirus, which has caused the COVID-19 pandemic.

限制使用

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For Research Use Only. Not For Use In Diagnostic Procedures.

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