Cilostazol #33528
Product Information
Product Usage Information
Cilostazol is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 0.90 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Product Description
| Molecular Weight | 369.5 g/mol |
| Purity | >98% |
| Molecular Formula | C20H27N5O2 |
| CAS | 73963-72-1 |
| Solubility | Soluble in DMSO at 20 mg/mL. |
Background
Cilostazol is a potent inhibitor (IC50 = 0.57 μM) of phosphodiesterase 3 (PDE3) and also inhibits the uptake of adenosine into muscle, endothelial cells, erythrocytes, and platelets (1). PDE3 hydrolyses both cAMP and cGMP, and plays a role in regulating cAMP-mediated signaling in a number of cell and tissue types, but is particularly important in regulating heart muscle, vascular smooth muscle, and platelet aggregation (2). Clinical studies demonstrate that Cilostazol is effective against inflammation, insulin resistance, and cardiomyopathy. Cilostazol, in conjunction with anti-platelet medication, reduced risk of restenosis, amputation, and target lesion revascularization following peripheral vascular interventions (3). Treatment of a murine model of obesity-associated left ventricular diastolic dysfunction with Cilostazol and hypertension medication resulted in improved left ventricular function and reduced TGF-β1/SMAD3 and Akt/mTOR signaling (4). Cilostazol is seen as more effective than aspirin in preventing recurrent ischemic stroke and intracranial hemorrhage (5), and as a potential treatment of Raynaud syndrome (6).
- Liu, Y. et al. (2001) Cardiovasc Drug Rev 19, 369-86.
- Movsesian, M. et al. (2018) J Cardiovasc Dev Dis 5, 10. doi: 10.3390/jcdd5010010.
- Warner, C.J. et al. (2014) J Vasc Surg 59, 1607-14.
- Reddy, S.S. et al. (2018) J Mol Cell Cardiol 123, 46-57.
- Lin, M.P. et al. (2021) J Stroke Cerebrovasc Dis 30, 105581.
- El-Hachem, N. et al. (2021) Curr Med Chem 28, 2409-2417.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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