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Render Timestamp: 2024-11-14T22:20:47.938Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-09-19 21:57:43.446
Product last modified at: 2024-09-19T22:12:47.469Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

Captopril #53537

    Product Information

    Product Usage Information

    Captopril is supplied as a lyophilized powder. For a 20 mM stock, reconstitute 5 mg of powder in 1.15 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 217.3 g/mol
    Purity >98%
    Molecular Formula C9H15NO3S
    CAS 62571-86-2
    Solubility Soluble in DMSO at 20 mg/ml or water at 20 mg/ml.

    Background

    Captopril is a selective and reversible angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 0.022 μM (1). This small molecule selectively lowers angiotensin II, a hormone that when upregulated has been linked to increased hypertension, atherosclerosis, myocardial hypertrophy, and obesity (2-5). Captopril has also been shown to regulate inflammatory pathways as a reversible inhibitor of leukotriene A4 (LTA4) hydrolase, reducing leukotriene B4 synthesis (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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