Render Target: SSR
Render Timestamp: 2024-12-19T20:41:47.311Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-19 21:57:44.173
Product last modified at: 2024-12-17T19:05:14.573Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Bromosporine

Bromosporine #97061

    Product Information

    Product Usage Information

    Bromosporine is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.23 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 404.4 g/mol
    Purity >98%
    Molecular Formula C17H20N6O4S
    CAS 1619994-69-2
    Solubility Soluble in DMSO at 25 mg/ml.

    Background

    Bromosporine is a potent broad-spectrum bromodomain inhibitor (1). Bromodomain and extra-terminal (BET) protein family members BRD2, BRD3, BRD4, and BRDT associate with acetylated lysines on histones and transcription factors to regulate their function, and have emerged as targets for cancer therapy (2,3). Treatment with Bromosporine induced the expression of latent HIV-1 in primary CD4+ T cells by inhibiting BET activity, leading to improved viral clearance in conjunction with antiretroviral therapy (4).

    限制使用

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