BC-11-38 #82556
Product Information
Product Usage Information
BC-11-38 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.10 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Product Description
| Molecular Weight | 304.4 g/mol |
| Purity | >98% |
| Molecular Formula | C15H16N2OS2 |
| CAS | 68770-80-9 |
| Solubility | Soluble in DMSO at 50 mg/mL or ethanol at 14 mg/mL. |
Background
The small-molecule BC-11-38 is an inhibitor of dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 (PDE11), which catalyzes hydrolysis of the second messengers cyclic guanosine 3', 5'-monophosphate (cGMP) and cyclic AMP (cAMP) in intracellular signaling regulation. BC-11-38 is a selective and potent inhibitor of PDE11, displaying IC50 values of less than 330 nM for PDE11 and a greater than 100-fold selectivity for PDE11 relative to other PDE isozymes. BC-11-38 treatment of human adrenocortical cells inhibited PDE11 and resulted in increased cAMP levels, cAMP-dependent protein kinase (PKA) activity, and cortisol production (1,2). At the time of its identification, BC-11-38 was thought of as a potential therapeutic target for the treatment of renal insufficiency (3).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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