Name: Bafilomycin A1
Price: 105.00 USD
Availability: InStock

Product Information

Product Usage Information

Bafilomycin A1 is supplied as a lyophilized powder. For a 1 mM stock, reconstitute the 100 μg in 160.56 μl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 10 nM-1 μM for up to 18 hr.

Storage

Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	622.8 g/mol
Purity	>98%
Molecular Formula	C₃₅H₅₈O₉
CAS	88899-55-2
Solubility	Soluble in DMSO at 50mg/ml.

Background

Isolated from Streptomyces griseus, bafilomycin A1 is a macrolide antibiotic that reversibly inhibits late phase autophagy (1,2). By inhibiting H⁺-ATPase, bafilomycin A1 prevents re-acidification of synaptic vesicles following exocytosis and thereby blocks fusion of autophagosomes and lysosomes (2-5). Research studies demonstrate that bafilomycin A1 can also inhibit cell proliferation (4).

限制使用

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For Research Use Only. Not For Use In Diagnostic Procedures.

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Bafilomycin A1 #54645