ABT-737 #93584
Product Information
Product Usage Information
ABT-737 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 615 μL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Product Description
| Molecular Weight | 813.4 g/mol |
| Purity | >98% |
| Molecular Formula | C42H45ClN6O5S2 |
| CAS | 852808-04-9 |
| Solubility | Soluble in DMSO at 5 mg/mL. |
Background
ABT-737 is a BH3 mimetic that is a potent inhibitor of multiple Bcl-2 family members, including Bcl-xL, Bcl-2, and Bcl-w that all have a Ki value of less than or equal to 1 nM (1,3). ABT-737 binds to these anti-apoptotic Bcl-2 family members and inhibits their interaction with pro-apoptotic BH3-domain proteins, leading to Bax-Bak mediated apoptosis. ABT-737 has cytotoxic activity in multiple cancer types, including small-cell lung cancer and lymphoid malignancies (2,3). It has also been shown to inhibit and regress tumor growth in xenograft tumor mouse models (3).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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