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Render Timestamp: 2024-12-26T18:45:34.234Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-11-13 14:07:05.871
Product last modified at: 2024-12-17T19:00:47.492Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. A 83-01

A 83-01 #75073

    Product Information

    Product Usage Information

    A 83-01 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.18 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 421.5 g/mol
    Purity >98%
    Molecular Formula C25H19N5S
    CAS 909910-43-6
    Solubility Soluble in DMSO at 20 mg/ml.

    Background

    A 83-01 is a potent and selective inhibitor of TGF-β type I receptor ALK5 kinase, activin type IB receptor ALK4, and nodal type I receptor ALK7 with an IC50 value of 12, 45, and 7.5 nM, respectively (1). This small molecule has also been shown to inhibit Smad2/3 phosphorylation along with TGF-β-induced growth inhibition and induction of Twist and Wnt3 (1,2). A 83-01 can be used to stabilize rat induced pluripotent stem cell (riPSC) cultures by inhibiting spontaneous differentiation and increasing the clonal expansion efficiency (3).

    限制使用

    除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。 任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受， 否书均被拒书，并且无效。

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