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XML generation date: 2024-10-25 16:26:06.750
Product last modified at: 2024-11-19T17:00:09.732Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Trichostatin A (TSA)

Trichostatin A (TSA) #9950

    Product Information

    Product Usage Information

    Trichostatin A is supplied as a lyophilized powder. For a 4mM stock (10.000X), reconstitute in 826 µL DMSO. Treat cells with 400 nM trichostatin A for 12-18 hours.

    Precautions: This compound is only sold for use in extremely dilute solutions for biological research. No other use is intended and any other use involves substantial hazards. This compound should never be handled in powder or aerosol form or in any other form susceptible to uncontrolled release in the laboratory, even in very small quantities.

    Storage

    Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 302.4 g/mol
    Purity >99%
    Molecular Formula C17H22N2O3
    CAS 58880-19-6
    Solubility Soluble in DMSO at 15mg/ml and EtOH at 3mg/ml.

    Background

    Trichostatin A is an antifungal antibiotic derived from Streptomyces that inhibits mammalian histone deacetylases (1,2). When used at nanomolar concentrations, trichostatin A causes the accumulation of acetylated histones in a quite specific and reversible manner (2,3). Trichostatin A has also been shown to inhibit both G1- and G2-phases of the mammalian cell cycle and has been tested for use as a potential anticancer agent (2-5).

    限制使用

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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