Lapatinib #12121

Name: Lapatinib
Price: 245.00 USD
Availability: InStock

Product Information

Product Usage Information

Lapatinib is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 10 mg in 1.08 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but is typically used at 0.1-10 µM either as a pretreatment for 0.5-2 hr prior to treating with a stimulator or used alone with varying treatment times lasting up to 72 hr.

Storage

Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	925.46 g/mol
Purity	>99%
Molecular Formula	C₂₉H₂₆ClFN₄O₄S•2C₇H₈O₃S
CAS	388082-77-7
Solubility	Soluble in DMSO at 200mg/ml.

Background

Lapatinib is a dual inhibitor of EGFR and HER2 tyrosine kinases (1-4). Researchers have shown that lapatinib inhibits purified EGFR and HER2 tyrosine kinase domains in cell-free kinase assays with IC₅₀ values of 10.8 nM and 9.2 nM, respectively, and HER4 with an IC₅₀ of 367 nM. Lapatinib was greater than 300-fold more selective for HER2 and EGFR than many other kinases, including c-src, MEK, Erk, and p38 in these assays (1). Studies have shown that lapatinib effectively inhibits both EGFR and HER2 autophosphorylation in cell types over expressing these kinases, and cell growth inhibition is correlated with HER2 overexpression (2-4).

限制使用

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For Research Use Only. Not For Use In Diagnostic Procedures.

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