CTGF (D8Z8U) Rabbit mAb (BSA and Azide Free) #92687
- WB
- IF
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 35 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
Formulation
Storage
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val174 of human CTGF protein.
Background
Connective tissue growth factor (CTGF, CCN2) belongs to the CCN (CYR61, CTGF, NOV) family of secreted extracellular matrix (ECM) proteins (1). Members of this family contain four conserved cysteine-rich domains, and interact in the ECM with a diverse array of cell surface receptors, including integrins and heparin-sulfate proteoglycans (2). These interactions regulate a multitude of cellular and tissue functions, including adhesion, proliferation, migration, differentiation, senescence, angiogenesis, inflammation, and wound repair (1,3-5). The CTGF gene is a transcriptional target of both YAP/TAZ and TGFβ-SMAD signaling pathways (6,7), and aberrant regulation of CTGF expression is strongly associated with pathological conditions, notably cancer and fibrosis (8,9).
- Chen, C.C. and Lau, L.F. (2009) Int J Biochem Cell Biol 41, 771-83.
- Gao, R. and Brigstock, D.R. (2004) J Biol Chem 279, 8848-55.
- Hall-Glenn, F. and Lyons, K.M. (2011) Cell Mol Life Sci 68, 3209-17.
- Hashimoto, G. et al. (2002) J Biol Chem 277, 36288-95.
- Ivkovic, S. et al. (2003) Development 130, 2779-91.
- Di Benedetto, A. et al. (2016) Oncotarget 7, 43188-43198.
- Liu, H. et al. (2015) Cell Biochem Biophys 73, 775-81.
- Brigstock, D.R. (2010) J Cell Commun Signal 4, 1-4.
- Jun, J.I. and Lau, L.F. (2011) Nat Rev Drug Discov 10, 945-63.
限制使用
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