CD48 (D7L8I) XP® Rabbit mAb (BSA and Azide Free) #90615
- WB
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 45-50 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
Formulation
Storage
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human CD48 protein.
Background
CD48 is a glycosylphosphatidylinositol (GPI) -anchored membrane protein of the signaling lymphocyte activation molecule (SLAM) family, also known as SLAMF2 and BLAST-1. It is constitutively expressed on most hematopoietic cells (not on neutrophils and a subset of long-term hematopoietic stem cells in mice) and can be upregulated under certain conditions like infection (1). Interaction with its low affinity ligand CD2 promotes adhesion and TCR signaling (2,3). Interaction with the high affinity ligand CD244 (2B4) regulates natural killer (NK) and CD8 T cell activation and cytolytic function (4-6).
- McArdel, S.L. et al. (2016) Clin Immunol 164, 10-20.
- Moran, M. and Miceli, M.C. (1998) Immunity 9, 787-96.
- Muhammad, A. et al. (2009) J Immunol 182, 7672-80.
- Assarsson, E. et al. (2005) Mol Immunol 42, 419-23.
- Assarsson, E. et al. (2005) J Immunol 175, 2045-9.
- Elishmereni, M. and Levi-Schaffer, F. (2011) Int J Biochem Cell Biol 43, 25-8.
限制使用
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