CD33 (F9U6X) Rabbit mAb #69590
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 70-80 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu316 of human CD33 protein.
Background
CD33, a type I transmembrane protein, is a sialic acid-binding Ig-like lectin 3 (Siglec-3) of the Ig superfamily, and human CD33 binds preferentially to alpha-2, 6-linked sialic acid. Upon binding to its ligands, CD33 transduces inhibitory signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its intracellular domain, inhibiting cellular functions such as phagocytosis. In addition, CD33 is also involved in other processes, such as adhesion (1-3). Due to its exclusive expression on hematopoietic cells, particularly the myeloid lineage and their progenitors, CD33 has been actively pursued as a therapeutic target against acute myeloid leukemia (AML) (4,5). CD33 may also be involved in Alzheimer’s Disease (AD) (6-8).
- Avril, T. et al. (2004) J Immunol 173, 6841-9.
- Cao, H. and Crocker, P.R. (2011) Immunology 132, 18-26.
- Crocker, P.R. et al. (2012) Ann N Y Acad Sci 1253, 102-11.
- Laszlo, G.S. et al. (2014) Blood Rev 28, 143-53.
- Laing, A.A. et al. (2017) Exp Hematol 54, 40-50.
- Jiang, T. et al. (2014) Mol Neurobiol 49, 529-35.
- Siddiqui, S.S. et al. (2017) J Biol Chem 292, 15312-20.
- Zhao, L. (2018) Gerontology, 1-9.
限制使用
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