MS4A4A (F2E6F) Rabbit mAb #33202
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 25 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val130 of human MS4A4A protein.
Background
Membrane-spanning 4-domains subfamily A member 4A (MS4A4A) is a member of a class of MS4A genes encoding four-transmembrane-spanning proteins (1,2). MS4A4A expression is enriched in human and mouse macrophages (3,4). Its expression in macrophages may be induced during macrophage development and activation (4). MS4A4A, via its interaction with the β-glucan receptor, Dectin-1, may contribute to macrophage-mediated production of proinflammatory cytokines and reactive oxygen species by activation of the Syk signaling pathway (4). Interestingly, MS4A4A, as well as other members of the MS4A gene cluster, is genetically linked to late-onset Alzheimer’s disease, suggesting that MS4A4A-dependent macrophage/microglia might contribute to neurodegenerative disease progression (5,6).
- Ma, J. et al. (2015) Mol Neurobiol 51, 1240-8.
- Villegas-Llerena, C. et al. (2016) Curr Opin Neurobiol 36, 74-81.
- Sanyal, R. et al. (2017) Immunol Cell Biol 95, 611-9.
- Mattiola, I. et al. (2019) Nat Immunol 20, 1012-22.
- Naj, A.C. et al. (2011) Nat Genet 43, 436-41.
- Deming, Y. et al. (2019) Sci Transl Med 11, eaau2291. doi: 10.1126/scitranslmed.aau2291.
限制使用
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