渲染靶标:SSR
Render Timestamp: 2025-03-17T21:34:49.989Z
Commit: 9fc0f116116d9da247dc8ddd4e5fe811153412e1
XML generation date: 2024-09-30 01:57:20.638
Product last modified at: 2025-01-01T09:04:48.769Z
1% for the Planet 标识
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PVRIG (E9X9B) Rabbit mAb #29599

Filter:
  • WB
  • IP
Western Blotting Image 1: PVRIG (E9X9B) Rabbit mAb
Western blot analysis of extracts from various human cells using PVRIG (E9X9B) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

To Purchase # 29599

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 30-40
Source/Isotype Rabbit IgG
Application Key:
  • WB-Western Blotting 
  • IP-Immunoprecipitation 
Species Cross-Reactivity Key:
  • H-Human 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000
Immunoprecipitation 1:200

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

PVRIG (E9X9B) Rabbit mAb recognizes endogenous levels of total PVRIG protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val325 of human PVRIG protein.

Background

Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein (PVRIG; also known as CD112 receptor) is a multiple transmembrane protein expressed on the surface of T cells and NK cells, predominantly on memory and effector CD8+ T cells. PVRIG expression is upregulated after in vitro T cell activation with anti-CD3 and anti-CD28 antibodies. PVRIG competes with DNAM-1/CD226 for interaction with the receptor ligand Nectin-2. Upon ligation of PVRIG and Nectin-2, T cell proliferation is inhibited, suggesting PVRIG is a co-inhibitory receptor that dampens T cell functions (1).
For Research Use Only. Not For Use In Diagnostic Procedures.
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