CD151 (E4I9J) XP® Rabbit mAb #96282
- WB
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:400 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly138 of human CD151 protein.
Background
CD151 (PETA-3, SFA-1) is a member of the evolutionarily conserved tetraspanin family of multipass glycoproteins (TM4SF), highlighted by four transmembrane domains, two extracellular loops, and N/C-termini that reside within the cytoplasm. Identified as the first member of the tetraspanin family to be implicated in tumorigenesis, research studies have demonstrated that CD151 participates in tumor neovascularization (1), tumor cell cell invasion (2), and cell adhesion (3). Furthermore, a positive correlation exists between CD151 expression levels and poor prognosis for tumors of the lung (4), kidney (5), and prostate (6). CD151 is localized predominantly to the plasma membrane and research studies have demonstrated that CD151 exerts its pro-tumorigenic effects, in part, through the modulation of laminin-binding integrins (7-9) and oncogenic receptor tyrosine kinases, such as c-Met (10,11) and EGFR (12).
- Takeda, Y. et al. (2007) Blood 109, 1524-32.
- Yauch, R.L. et al. (1998) Mol Biol Cell 9, 2751-65.
- Zhang, F. et al. (2011) Blood 118, 4274-84.
- Tokuhara, T. et al. (2001) Clin Cancer Res 7, 4109-14.
- Yoo, S.H. et al. (2011) Histopathology 58, 191-7.
- Ang, J. et al. (2004) Cancer Epidemiol Biomarkers Prev 13, 1717-21.
- Sincock, P.M. et al. (1999) J Cell Sci 112 ( Pt 6), 833-44.
- Winterwood, N.E. et al. (2006) Mol Biol Cell 17, 2707-21.
- Liu, L. et al. (2007) J Biol Chem 282, 31631-42.
- Klosek, S.K. et al. (2009) Biochem Biophys Res Commun 379, 1097-100.
- Franco, M. et al. (2010) J Biol Chem 285, 38756-64.
- Yang, X.H. et al. (2008) Cancer Res 68, 3204-13.
限制使用
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