ALDH1A1 (D9Q8E) XP® Rabbit mAb (PE Conjugate) #65583
- F
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Description
Product Usage Information
| Application | Dilution |
|---|---|
| Flow Cytometry (Fixed/Permeabilized) | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ALDH1A1 protein.
Background
The aldehyde dehydrogenase family is a large group of enzymes that oxidize aldehydes formed through metabolic processes to their carboxylic acids (1). ALDH1A1 is a liver cytosolic isoform of acetaldehyde dehydrogenase and is involved in the major pathway of alcohol metabolism along with alcohol dehydrogenase (2). ALDH1A1 is also known as retinal dehydrogenase 1 and is involved in retinol metabolism, converting retinol to retinoic acid (3). Recent studies suggest that control of retinoid signaling through ALDH1A1 may influence hematopoietic stem cell differentiation (4). There has been recent interest in ALDH1 isoforms as predictive biomarkers in disease. Several studies have suggested that ALDH1A1 is a potential marker for cancer stem cells and chemoresistance in several tumor types, such as melanoma (5), lung cancer (6), and glioblastoma (7).
- Jackson, B. et al. (2011) Hum Genomics 5, 283-303.
- Edenberg, H.J. (2007) Alcohol Res Health 30, 5-13.
- Duester, G. (2000) Eur J Biochem 267, 4315-24.
- Chute, J.P. et al. (2006) Proc Natl Acad Sci U S A 103, 11707-12.
- Luo, Y. et al. (2012) Stem Cells 30, 2100-13.
- Huang, C.P. et al. (2013) Cancer Lett 328, 144-51.
- Schäfer, A. et al. (2012) Neuro Oncol 14, 1452-64.
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