Render Target: SSR
Render Timestamp: 2024-08-29T22:18:44.926Z
Commit: 419142f0105700b709b94a8ebde4734bae2c62a3
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MYO10 (F3V7U) Rabbit mAb #54922

Filter:
  • WB
  • IP
  • IF

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 237
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100
    Immunofluorescence (Immunocytochemistry) 1:50 - 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MYO10 (F3V7U) Rabbit mAb recognizes endogenous levels of total MYO10 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the central region of human MYO10 protein.

    Background

    Myosin family motor proteins drive ATP-dependent actin-based motility in eukaryotic cells and contain a conserved amino-terminal motor domain (1). Unconventional myosin-X (MYO10) binds actin filaments and localizes to filopodia tips. MYO10 regulates cell migration, metastasis, and neuritogenesis, and its expression is upregulated in mouse and human tumors (2). MYO10 was shown to drive tumor progression by inducing genome instability through cGAS/STING inflammatory response (3). Regulation of MYO10 phosphorylation and protein levels in mitosis is critical for spindle formation, genome stability, and sensitivity of cancer cells to Taxol (4).

    For Research Use Only. Not For Use In Diagnostic Procedures.
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