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#67088
Store at -20C
Stat3/Stat5 Signaling Antibody Sampler Kit
1 Kit
(6 x 20 microliters)
877-616-CELL (2355)
877-678-TECH (8324)
3 Trask Lane | Danvers | Massachusetts | 01923 | USA
For Research Use Only. Not for Use in Diagnostic Procedures.
Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
---|---|---|---|---|
Stat3 (D3Z2G) Rabbit mAb | 12640 | 20 µl | 79, 86 kDa | Rabbit IgG |
Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb | 9145 | 20 µl | 79, 86 kDa | Rabbit IgG |
Stat5 (D2O6Y) Rabbit mAb | 94205 | 20 µl | 90 kDa | Rabbit IgG |
Phospho-Stat5 (Tyr694) (D47E7) XP® Rabbit mAb | 4322 | 20 µl | 90 kDa | Rabbit IgG |
Jak2 (D2E12) XP® Rabbit mAb | 3230 | 20 µl | 125 kDa | Rabbit IgG |
Phospho-Jak2 (Tyr1007) (D15E2) Rabbit mAb | 4406 | 20 µl | 125 kDa | Rabbit IgG |
Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
Please visit cellsignal.com for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.
Description
Storage
Background
In the context of hematopoiesis, Stat3 and Stat5 may act antagonistically (12,13). Stat3 activity can promote differentiation of myeloid progenitor cells into neutrophils in a granulocyte colony-stimulating factor (G-CSF)-dependent manner, while Stat5 activation results in inhibition of this pathway in a granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent manner (13). Stat5 activity upregulates SOCS3, which subsequently inhibits Stat3 and results in differentiation to monocytes and macrophages (13). In addition to their roles in regulating gene expression as transcription factors, Stat3 and Stat5 are also capable of altering chromatin landscapes through recruitment of chromatin remodeling enzymes (14,15). While they serve many key functions in normal growth and development, if disrupted, the Jak2/Stat3 and Jak2/Stat5 signaling axes contribute to various diseases, including many types of cancer, non-alcoholic fatty liver disease, and eosinophilic cellulitis (16-20).
Background References
- Darnell Jr., J. et al. (1994) Science 264, 1415-1421.
- Leonard, W.J. and O'Shea, J.J. (1998) Annu. Rev. Immunol. 16, 293-322.
- Caldenhoven, E. et al. (1996) J. Biol. Chem. 271, 13221-13227.
- Wen, Z. et al. (1995) Cell 82, 241-250.
- Yokogami, K. et al. (2000) Curr. Biol. 10, 47-50.
- Lim, C.P. and Cao, X. (1999) J. Biol. Chem. 274, 31055-31061.
- Bromberg, J. F. et al. (1999) Cell 98, 295-303.
- Su, L. et al. (1999) J. Biol. Chem. 274, 31770-31774.
- Dentelli, P. et al. (1999) J. Immunol. 163, 2151-2159.
- Cattaneo, E. et al. (1999) Trends Neurosci. 22, 365-369.
- Frank, D.A. (1999) Mol. Med. 5, 432-456.
- Cohen, P.A. et al. (2008) Blood 112, 1832-43.
- Zhang, M. et al. (2023) Cell Death Discov. 9, 274.
- Wingelhofer, B. et al. (2018) Leukemia 32, 1713-1726.
- Orlova, A. et al. (2019) Cancers (Basel) 11, 1930.
- Warsch, W. et al. (2013) Blood 122, 2167-75.
- Halim, C.E. et al. (2020) Biomedicines 8, 316.
- Huang, B. et al. (2022) Front. Oncol. 12, 1023177.
- Kaltenecker, D. et al. (2019) Cytokine 124, 154569.
- Morot, J. et al. (2023) JAMA Dermatol. 159, 820-829.
Trademarks and Patents
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
XP is a registered trademark of Cell Signaling Technology, Inc.
All other trademarks are the property of their respective owners. Visit cellsignal.com/trademarks for more information.
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