5-HTR4 (D8O5K) Rabbit mAb recognizes endogenous levels of total 5-HTR4 protein.

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala361 of human 5-HTR4 protein.

Serotonin (5-hydroxytryptamine, 5-HT) is a central nervous system monoamine implicated in a number of physiological functions, including sleep, mood, appetite, anxiety, and neurovegetative control (1). Serotonin acts through the activation of G protein receptors called serotonin receptors (5-HTRs). Seven 5-HTR subclasses (5-HTR1-7) have been described to date (2). Serotonin receptor 4 (5-HTR4) couples to Gαs (3), with stimulation of the receptor leading to adenylyl cyclase activation, elevation of cyclic AMP levels and downstream PKA activation (4). The corresponding HTR4 gene exhibits a complex structure, which includes a large number of splice variants that seem to share the same pharmacological properties (5). 5-HTR4 is one of several receptors implicated in cognition, depression, and the development of Alzheimer's disease (6-8).